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  • Title: Stabilizing HIF to Ameliorate Anemia.
    Author: Voit RA, Sankaran VG.
    Journal: Cell; 2020 Jan 09; 180(1):6. PubMed ID: 31951520.
    Abstract:
    Erythropoietin (EPO) production in the kidney is regulated by the oxygen-sensing transcription factor HIF-1α, which is degraded under normoxic conditions by HIF-prolyl hydroxylase (HIF-PHD). Inhibition of HIF-PHD by roxadustat leads to increased EPO production, better iron absorption, and amelioration of anemia in chronic kidney disease (CKD).
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