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  • Title: Preparation of a Sandwich-like Complex "MIPs-Target Molecule-Magnetic SERS Probe" and SERS Determination of Immunoglobulin G.
    Author: Li X, Li L, He Y.
    Journal: Anal Sci; 2020 Sep 10; 36(9):1025-1030. PubMed ID: 31956158.
    Abstract:
    Based on the reversible covalent binding between borates and glycoproteins, we proposed a scheme that can specifically recognize and detect immunoglobulin G (IgG). The application of magnetic materials to enrich SERS probes can provide an enhanced signal and repeatability. The results showed that the prepared sandwich-like complex displayed high sensitivity and excellent selectivity for IgG. The Raman peak intensity showed a good linear relationship in the concentration range of 1 mg/mL - 1 ng/mL. The linear equation was y = 657.93x + 2963.9, R2 = 0.996. Parallel testing of this sandwich-like complex proved to have excellent repeatability. This method provided a new possibility for clinical non-immunity and the quantitative detection of IgG.
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