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  • Title: Self-Assembly of Porphyrin-Containing Metalla-Assemblies and Cancer Photodynamic Therapy.
    Author: Jiang X, Zhou Z, Yang H, Shan C, Yu H, Wojtas L, Zhang M, Mao Z, Wang M, Stang PJ.
    Journal: Inorg Chem; 2020 Jun 01; 59(11):7380-7388. PubMed ID: 31961145.
    Abstract:
    In this report, we describe the synthesis of two porphyrin-containing Pt(II) supramolecular assemblies via coordination-driven self-assembly. X-ray crystallographic analysis on one assembly reveals that the metalla-assembly formation imposes large interchromophore distances, leading to a higher 1O2 generation efficiency, relative to the corresponding small molecular precursors. The metalla-assemblies were examined as photosensitizers for photodynamic therapy as the potential reduction of the unfavorable self-aggregation phenomenon. In vivo and in vitro investigations demonstrate that the metalla-assemblies exhibit enhanced anticancer activity with minimal dose requirement and side effects comparable to the small molecule precursors. Thus, our work demonstrates that self-assembly provides a promising methodology for enhancing the therapeutic effectiveness of anticancer agents.
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