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  • Title: Isocadiolides A-H: Polybrominated Aromatics from a Synoicum sp. Ascidian.
    Author: Bae J, Cho E, Park JS, Won TH, Seo SY, Oh DC, Oh KB, Shin J.
    Journal: J Nat Prod; 2020 Feb 28; 83(2):429-437. PubMed ID: 31967465.
    Abstract:
    Isocadiolides A-H (1-8) and cadiolide N (9), new polybrominated aromatic compounds, were isolated from a Korean Synoicum sp. ascidian. On the basis of the results of extensive spectroscopic analyses, these compounds possessed tris-bromohydroxyphenyl moieties as a common structural motif, while their cores varied [cyclopentenedione (1-5), dihydrofuran (6 and 7), pyranone (8), and furanone (9)], reflecting different extents of rearrangement and oxidation. Several of these compounds exhibited weak antibacterial activities and moderate abilities to inhibit the microbial enzymes sortase A and isocitrate lyase.
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