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  • Title: [Effect of adaptation to hypoxia on the antioxidant enzyme activity in the liver in animals that have undergone stress].
    Author: Tverdokhlib VP, Konovalova GG, Lankin VZ, Meerson FZ.
    Journal: Biull Eksp Biol Med; 1988 Nov; 106(11):528-9. PubMed ID: 3196845.
    Abstract:
    It was shown in experiments on rats that emotional-painful stress resulted in a rapid increase in malonic dialdehyde (MDA) and in a decrease in the activity of superoxide dismutase (SOD) in liver. Adaptation to moderate intermittent hypoxia in altitude chamber did not affect MDA and increased hepatic SOD by 65%. Stress exposure caused no change in SOD and MDA, but abruptly reduced the fall of SOD in adapted animals. These data are in accordance with the well-known idea that adaptation to hypoxia prevents the activation of lipid peroxidation and the hepatic damage in stress.
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