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  • Title: Dependence with nutritional status of the ethanol effects on fatty acid metabolism in rat hepatocytes.
    Author: Maquedano A, Guzmán M, Castro J.
    Journal: Int J Biochem; 1988; 20(9):937-41. PubMed ID: 3197909.
    Abstract:
    1. The effects of ethanol on fatty acid synthesis, esterification and oxidation were studied in hepatocytes isolated from fed and 24 hr fasted rats. 2. [3H]H2O was preferentially incorporated into the glycerol backbone of triglycerides and phospholipids. Addition of ethanol markedly increased the incorporation of this label in both classes of glycerolipids; the increase was higher in fasted rat hepatocytes, both in the glycerol backbone and acyl groups of glycerolipids. 3. Ethanol increased [U-14C]palmitate incorporation into triglycerides only in hepatocytes from fasted rats. 4. [14C]CO2 and total acid soluble product formation from [1-14C]palmitate resulted inhibited by ethanol both in the fed and the fasted state.
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