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  • Title: Detection of O4-ethylthymine in human liver DNA.
    Author: Huh N, Satoh MS, Shiga J, Kuroki T.
    Journal: IARC Sci Publ; 1988; (89):292-5. PubMed ID: 3198212.
    Abstract:
    O4-Ethyl-2'-deoxythymidine (O4-EtdThy) in human liver DNA was quantified, in order to monitor possible human exposure to ethylating agents, using a highly sensitive immunological detection method. In 30 of 33 cases analysed, O4-EtdThy was detected at above the detection limit (i.e., 3 x 10(-8) O4-EtdThy/2'-deoxy-thymidine[dThy]), indicating actual chronic exposure to ethylating agents. The mean content of O4-EtdThy in 19 cases of malignant tumours was significantly higher than that in 11 nonmalignant cases (p less than 0.05).
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