These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Sympathetic activity and food intake of rats with ventromedial hypothalamic lesions.
    Author: Sakaguchi T, Arase K, Bray GA.
    Journal: Int J Obes; 1988; 12(4):285-91. PubMed ID: 3198309.
    Abstract:
    Following ventromedial hypothalamic lesions, food intake increased from 60 to slightly more than 77 kcal/day during the first 6 days. Body weight increased and sympathetic activity, as measured by the electrical firing rate of efferent nerves to interscapular brown adipose tissue, decreased significantly. During a 6-day period of intragastric overfeeding in which animals with hypothalamic lesions received 60 kcal for the first day and 80 kcal for the remaining 5 days, the VMH-lesioned animals gained significantly more weight than the intact, sham-lesioned controls. This difference in weight gain was paralleled by the increased weight of liver and white adipose tissue. The lesioned animals showed a highly significant reduction in sympathetic activity compared to the normal or slightly increased values observed in the sham-lesioned animals. These studies are consistent with the hypothesis that food-induced increases in sympathetic activity are modulated by the ventromedial hypothalamus.
    [Abstract] [Full Text] [Related] [New Search]