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  • Title: A new macromolecular antitumor antibiotic, C-1027. II. Isolation and physico-chemical properties.
    Author: Otani T, Minami Y, Marunaka T, Zhang R, Xie MY.
    Journal: J Antibiot (Tokyo); 1988 Nov; 41(11):1580-5. PubMed ID: 3198492.
    Abstract:
    A new macromolecular antibiotic C-1027 was obtained from the broth filtrate of Streptomyces globisporus C-1027 by precipitation with ammonium sulfate, DEAE-cellulose column chromatography and gel filtration chromatography on a Sephadex G-75 column. This antibiotic, prepared as a white powder, is an acidic polypeptide having an isoelectric point of pH 3.5-3.7 and a molecular weight of 15,000 as determined by SDS-polyacrylamide gel electrophoresis and gel filtration chromatography. The acid hydrolysate of the purified antibiotic C-1027 contained no methionine or tryptophan. From the physico-chemical data, it may be considered to possess a very labile non-protein chromophore.
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