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  • Title: Quinoline Containing Side-chain Antimalarial Analogs: Recent Advances and Therapeutic Application.
    Author: Joshi MC, Egan TJ.
    Journal: Curr Top Med Chem; 2020; 20(8):617-697. PubMed ID: 31985377.
    Abstract:
    The side-chains of quinoline antimalarial agents are the major concern of focus to build novel and efficaciaous bioactive and clinical antimalarials. Bioative antimalarial analogs may play a critical role in pH trapping in the food vacuole of RBC's with the help of fragmented amino acid, thus lead to β-hematin inhibition. Here, the authors tried to summarize a useful, comprehensive compilation of side-chain modified ACQs along with their synthesis, biophysical and therapeutic applications etc. of potent antiplasmodial agents and therefore, opening the door towards the potential clinical status.
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