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  • Title: Physicochemical, toxicological and hygienic aspects of ethylene oxide application for the sterilization of medical products. III. Setting hygienic norms in sterilized medical products.
    Author: Lyarsky PP, Gleiberman SYe, Likhtman TV, Kopylova LS, Zayeva GN, Yurchenko VV, Kolesnikova NI, Kareev NV.
    Journal: J Hyg Epidemiol Microbiol Immunol; 1988; 32(3):257-64. PubMed ID: 3198908.
    Abstract:
    Some of the drawbacks are discussed associated with hygienic norms for gaseous sterilizing agents in polymeric products for medical applications. A new approach is proposed for regulating ethylene oxide (EO) in such products. To this end, limiting types of biological effect and its pathways have been determined and substantiated as well as the reliability factor for establishing hygienic norms for EO in medical products. Daily threshold EO limit values were calculated for momentary and repeated exposure of humans. The duration of long-term and short-term exposure of the patient to sterilized products was evaluated on the basis of EO extraction kinetics from a variety of materials. Using daily threshold limit values, threshold residual values (TRV) of EO were calculated for different groups of polymeric products for medical applications.
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