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  • Title: Distal Alkenyl C-H Functionalization via the Palladium/Norbornene Cooperative Catalysis.
    Author: Wu Z, Fatuzzo N, Dong G.
    Journal: J Am Chem Soc; 2020 Feb 12; 142(6):2715-2720. PubMed ID: 31995370.
    Abstract:
    A distal-selective alkenyl C-H arylation method is reported through a directed palladium/norbornene (Pd/NBE) cooperative catalysis. The key is to use an appropriate combination of the directing group and the NBE cocatalyst. A range of acyclic and cyclic cis-olefins are suitable substrates, and the reaction is operated under air with excellent site-selectivity. Preliminary mechanistic studies are consistent with the proposed Pd/NBE-catalyzed C-H activation instead of the Heck pathway. Initial success on distal alkylation has also been achieved using MeI and methyl bromoacetate as electrophiles.
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