These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Association between interleukin-10 -1082A/G polymorphism and risk of ischemic stroke: A meta-analysis.
    Author: Zuo S, Zheng T, Li H.
    Journal: Medicine (Baltimore); 2020 Jan; 99(5):e18858. PubMed ID: 32000388.
    Abstract:
    The Interleukin-10 -1082A/G polymorphism has been indicated to be correlated with ischemic stroke susceptibility, but the results of studies are still debatable. Thus, a meta-analysis was carried out.Databases including PubMed, Embase, and CNKI were searched. Data were extracted and odds ratios (OR) with 95% confidence intervals (CI) were calculated.12 case-control studies with 2722 cases and 2405 controls were included in this meta-analysis. IL-10 -1082A/G polymorphism may decrease the risk of ischemic stroke (G vs A: OR = 0.72, 95% CI: 0.59-0.87; GG vs AA: OR = 0.59, 95% CI:0.48-0.74; AG vs AA: OR = 0.69, 95% CI: 0.51-0.93; GG+AG vs AA: OR = 0.65, 95% CI: 0.50-0.84; GG vs AG+AA: OR = 0.71, 95% CI: 0.55-0.93). Meanwhile, similar results were also observed in matched studies, hospital-based subgroup, Asians, and large sample-size studies.In conclusion, this meta-analysis suggested that the IL-10 -1082A/G polymorphism contributes to decreased ischemic stroke risk. Further large-scale and well-designed studies are still needed to confirm the results of our meta-analysis.
    [Abstract] [Full Text] [Related] [New Search]