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Title: [Study on the white matter neuronal integrity in amnestic mild cognitive impairment based on automating fiber-tract quantification].
Author: Li WP, Zhao H, Zhang X, Liang X, Liu Y, Zhang W, Zhang B.
Journal: Zhonghua Yi Xue Za Zhi; 2020 Jan 21; 100(3):172-177. PubMed ID: 32008281.
Abstract:
Objective: To analyze the pattern of the change in cerebral white matter tract in amnestic mild cognitive impairment (aMCI) patients based on the automating fiber-tract quantification (AFQ). Methods: A total of 20 aMCI patients,9 males,11 females, the mean age was (67±9) years, and 22 patients with naMCI, 8 males,14 females, the mean age was (64±10) years, and 23 normal control subjects, 10 males, 13 females, with a mean age of (65±9) years were enrolled from the Affiliated Drum Tower Hospital of Nanjing University Medical School from January 2018 to March 2019. All of them underwent 3.0 T MRI scan, which include DTI and 3D T(1)WI sequence.Two tract profiles, fractional anisotropy (FA) and mean diffusivity (MD), were extracted to evaluate the white matter integrity at 100 locations along each of 20 fiber tracts based on the AFQ. Results: In a pointwise comparison of FA profiles,the aMCI patients showed FA reduction in the middle part of right corticospinal tract (t=-4.023, P<0.01, FWE corrected) relative to the naMCI patients. There was a positive correlation between the decreased FA value and the auditory verbal learning test score (P=0.039). In a pointwise comparison of MD profiles, the aMCI patients showed extensive MD elevation in the middle part of the left cingulum hippocampus (t=2.408,P=0.037,FWE corrected) relative to the naMCI patients. The aMCI patients showed MD elevation in the posterior part of the left inferior longitudinal fasciculus (t=-2.919, P=0.006, FWE corrected) and the middle part of the left cingulum hippocampus (t=-3.878, P=0.002, FWE corrected) relative to the NC subjects. And the elevated MD in left inferior longitudinal fasciculus showed negative correlation with MoCA (P=0.039) and auditory verbal learning test score (P=0.015). There was also a negative correlation between the elevated MD value in the left cingulum hippocampus and the auditory verbal learning test score (P=0.033). Conclusions: Disruption is found in specific part along the white matter tract in the aMCI group. Furthermore, the pattern of white matter abnormalities is different across neuronal fiber tracts. These findings will have an impact on the further specific study of the white matter tract in aMCI patients. 目的： 采用纤维束自动定量法（AFQ）对遗忘型认知障碍患者（aMCI）的脑白质纤维束部分各向异性（FA）值及平均扩散率（MD）进行分析，以研究患者脑内白质纤维束逐点破坏的特点。 方法： 选取2018年1月至2019年3月在南京大学医学院附属鼓楼医院神经内科记忆门诊就诊的20例aMCI患者，男9例、女11例，平均年龄（67±9）岁；22例非遗忘型认知障碍（naMCI）患者，男8例、女14例，平均年龄（64±10）岁；年龄、性别、受教育程度匹配的23名健康对照（NC），男10名、女13名，平均年龄（65±9）岁，所有被试者均进行3.0 T磁共振扩散张量成像及高分辨T(1)加权成像扫描，采用AFQ对全脑20根纤维束的100个节点进行FA及MD值定量分析。 结果： 脑白质纤维束FA值的逐点分析显示，aMCI患者右侧皮质脊髓束中间节段（节点33~60）明显低于naMCI患者（t=-4.023，P<0.01，FWE校正），且FA值与听觉词语记忆测试正相关（P=0.039）。脑白质纤维束MD值的逐点分析显示，aMCI患者左侧扣带束海马部分的中间节段（节点41~61）明显高于naMCI患者（t=2.408，P=0.037，FWE校正），aMCI患者左侧下纵束偏后部（节点24~46）（t=-2.919，P=0.006，FWE校正）及左侧扣带束海马的中间节段（节点38~71）（t=-3.878，P=0.002，FWE校正）明显高于健康对照组，且左侧下纵束平均MD值分别与MoCA（P=0.039）及听觉词语记忆测试得分（P=0.015）呈负相关关系，左侧扣带束海马平均MD值与听觉词语记忆测试得分呈负相关关系（P=0.033）。 结论： aMCI患者部分纤维束的特定节点会出现一定损伤，且与神经心理学量表相关。此外，不同的白质纤维束破坏模式各异；较之前的其他类似研究明显改进了定量分析方法，对进一步理解aMCI患者脑白质纤维束破坏模式具有重要价值。.

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