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  • Title: Evidence for potentiation of lipid peroxidation in the rat liver after chronic ethanol feeding.
    Author: Yamada S, Fujiwara K, Masaki N, Ohta Y, Sato Y, Oka H.
    Journal: Scand J Clin Lab Invest; 1988 Nov; 48(7):627-32. PubMed ID: 3201094.
    Abstract:
    Hepatic steatosis was induced in rats by feeding nutritionally adequate liquid diet containing ethanol as 36% of energy for 4-5 weeks. After 24 h fasting and withdrawal from ethanol, liver ischaemia for 30 min followed by 2 h reperfusion resulted in a significant increase in microsomal lipid peroxide content and a decrease in reduced glutathione content as well as in protein synthesis with a rapid accumulation of triglyceride in the liver. In rats fed a non-ethanol diet or those fed a high-cholesterol diet with hepatic steatosis, however, similar phenomena were not found. These findings suggest that chronic ethanol feeding potentiates hepatic lipid peroxidation.
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