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  • Title: Norvaline accumulation by regulatory mutants of Serratia marcescens.
    Author: Kisumi M, Sugiura M, Takagi T, Chibata I.
    Journal: J Antibiot (Tokyo); 1977 Jan; 30(1):111-7. PubMed ID: 320169.
    Abstract:
    A gene coding for desensitized L-threonine dehydratase was transduced with phage PS20 into a leucine accumulator of Serratia marcescens Sr41. The transductant converted L-threonine to alpha-ketobutyrate, a precursor of both norvaline and isoleucine. An isoleucine-valine auxotroph of the transductant accumulated large amount of norvaline from L-threonine as well as from D-threonine.
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