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  • Title: Further Investigations into Rigidity-Activity Relationships in BisQAC Amphiphilic Antiseptics.
    Author: Leitgeb AJ, Feliciano JA, Sanchez HA, Allen RA, Morrison KR, Sommers KJ, Carden RG, Wuest WM, Minbiole KPC.
    Journal: ChemMedChem; 2020 Apr 20; 15(8):667-670. PubMed ID: 32022457.
    Abstract:
    Thirty-six biscationic quaternary ammonium compounds were efficiently synthesized in one step to examine the effect of molecular geometry of two-carbon linkers on antimicrobial activity. The synthesized compounds showed strong antimicrobial activity against a panel of both Gram-positive and Gram-negative bacteria, including methicillin-resistant Staphylococcus aureus (MRSA). While the linker geometry showed only a modest correlation with antimicrobial activity, several of the synthesized bisQACs are promising potential antiseptics due to good antimicrobial activity (MIC≤2 μM) and their higher therapeutic indices compared to previously reported QACs.
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