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  • Title: Assessment of lung water distribution by nuclear magnetic resonance. A new method for quantifying and monitoring experimental lung injury.
    Author: Cutillo AG, Morris AH, Ailion DC, Case TA, Durney CH, Ganesan K, Watanabe F, Akhtari M.
    Journal: Am Rev Respir Dis; 1988 Jun; 137(6):1371-8. PubMed ID: 3202373.
    Abstract:
    We have developed a new analytical method that uses nuclear magnetic resonance (NMR) imaging data to quantify lung water content and distribution. This new method generates a distribution of lung water density in which the fraction of voxels corresponding to a given water density is plotted on the vertical axis as a function of water density on the horizontal axis, thereby complementing the spatial information provided by the NMR image. We obtained reproducible lung water distribution data at comparable lung volumes in normal excised lungs and in intact living rats. In normal excised unperfused rat lungs, the distribution varied with the degree of inflation, but the changes were small compared with those associated with lung edema. The lung water density distribution changed markedly after induction of lung edema by intrabronchial saline instillation, intravenous oleic acid injection, and rapid intravenous saline infusion. Lung water density distribution data were well correlated (correlation coefficient = 0.948 for the excised lungs and 0.823 for the intact living rats) with gravimetric lung water measurements. The new analytical method is noninvasive, provides easily repeatable measurements, and is as sensitive as the gravimetric technique to lung water changes.
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