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  • Title: Gamma glutamyl transferase: application of a new radiochemical assay to the analysis of its subcellular distribution in the rat liver.
    Author: Malvoisin E, Mercier M, Roberfroid M.
    Journal: Enzyme; 1978; 23(6):373-81. PubMed ID: 32026.
    Abstract:
    gamma-Glutamyl transferase (gamma-GT) is a key catalyst in the metabolism of glutathione. Its activity in the rat liver is usually very low but it increases significantly during the process of chemical hepatocarcinogenesis. A new radiochemical assay is reported which measures the amount of 3H-aniline liberated from gamma-glutamyl-3H-anilide. This assay is highly specific and no biological substances interferes. By applying this new assay to the analysis of the subcellular distribution of the rat liver gamma-GT, it is shown that it distributes between two pools, one which corresponds to a membrane-bound enzyme, the other to a soluble enzyme. The subcellular distribution of gamma-GT is discussed by comparison with the patterns of distribution of classical marker enzymes.
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