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  • Title: Different effects of 2-deoxy-sugars on memory formation.
    Author: Grecksch G, Pohle W, Jork R, Matthies H.
    Journal: Biomed Biochim Acta; 1988; 47(7):655-61. PubMed ID: 3202851.
    Abstract:
    When rats were trained on a brightness discrimination task, intrahippocampal injections of 2-deoxy-galactose interfered with long-term memory formation while galactose and 2-deoxy-glucose were ineffective altogether. No differences were found in the morphology of hippocampal CA1 neurons investigated light-microscopically after application of the sugars. The amnestic action of 2-deoxy-galactose is discussed in the light of a rather specific interference with fucosylation of proteoglycans involved in mechanisms underlying the formation of a memory trace.
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