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  • Title: Characterization of activin A binding sites on the human leukemia cell line K562.
    Author: Campen CA, Vale W.
    Journal: Biochem Biophys Res Commun; 1988 Dec 15; 157(2):844-9. PubMed ID: 3202879.
    Abstract:
    Recombinant activin A was radioiodinated to a high specific activity with maintenance of bioactivity using the Bolton-Hunter method. The human leukemia cell line K562, known to differentiate in response to activin A, was found to possess high affinity [125I]BH-activin A receptors (Kd approximately 0.13 nM) with a low number of receptors per cell (approximately 600 per cell). This receptor was found to be specific as FSH, LH, GnRH, and TGF-beta 1 do not compete for binding. This is the first description of binding sites for this protein hormone on K562 cells.
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