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  • Title: Manipulating regioselectivity of an epoxide hydrolase for single enzymatic synthesis of (R)-1,2-diols from racemic epoxides.
    Author: Hu D, Zong XC, Xue F, Li C, Hu BC, Wu MC.
    Journal: Chem Commun (Camb); 2020 Mar 03; 56(18):2799-2802. PubMed ID: 32030396.
    Abstract:
    Both the activity and regioselectivity of Phaseolus vulgaris epoxide hydrolase were remarkably improved via reshaping two substrate tunnels based on rational design. The elegant one-step enantioconvergent hydrolysis of seven rac-epoxides was achieved by single mutants, allowing green and efficient access to valuable (R)-1,2 diols with high eep (90.1-98.3%) and yields.
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