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  • Title: Lymphocytic colitis in the setting of teriflunomide use for relapsing multiple sclerosis.
    Author: Son M, McEwan L, Ubaidat M, Bovell K, Morrow SA.
    Journal: Mult Scler; 2020 Nov; 26(13):1801-1803. PubMed ID: 32031458.
    Abstract:
    Teriflunomide is an oral monotherapy used to treat relapsing multiple sclerosis. Although teriflunomide may be associated with gastrointestinal symptoms, these events are mild and self-limiting. We present a 39-year-old female who developed severe diarrhea and lost 20 pounds within 3 weeks of starting teriflunomide. Despite discontinuing teriflunomide and undergoing cholestyramine washout, her symptoms persisted. Celiac disease on genetic testing was positive, but no anti-transglutaminase and anti-endomysial antibodies were detected. She underwent colonoscopy and biopsy was consistent with lymphocytic colitis. Remission was achieved within days of starting budenoside. Our case describes a rare, but serious, gastrointestinal adverse event of teriflunomide.
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