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  • Title: The heme biosynthetic pathway in lymphocytes of patients with malignant lymphoproliferative disorders.
    Author: Schoenfeld N, Epstein O, Lahav M, Mamet R, Shaklai M, Atsmon A.
    Journal: Cancer Lett; 1988 Dec 01; 43(1-2):43-8. PubMed ID: 3203329.
    Abstract:
    The metabolism of heme is impaired in lymphocytes of patients with malignant lymphoproliferative disorders (MLPO). Two of the enzymes of the heme biosynthetic pathway, delta-aminolevulinic acid dehydrase (ALAD) (EC 4.2.1.24) and ferrochelatase (FC) (EC 4.99.1.1) are markedly reduced. The activity of porphobilinogen deaminase (PBGD) (EC 4.3.1.8) is increased. The rate-limiting enzyme of heme biosynthesis in the liver, aminolevulinate synthase (ALAS) (EC 2.3.1.37) remains unchanged although the concentration of total heme in the lymphocytes is markedly reduced. This might reflect a lack of negative feedback inhibition by heme on ALAS activity in this system.
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