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  • Title: Analysis of open-loop and L2∕D controlled closed-loop behavior of the Cholette's bioreactor under different operating conditions.
    Author: Carrillo-Ahumada J, Reynoso-Meza G, Ruiz-López II, García-Alvarado MA.
    Journal: ISA Trans; 2020 Jun; 101():147-159. PubMed ID: 32057421.
    Abstract:
    The scope of this paper is the analysis of open-loop and L2/D controlled closed-loop behavior of the Cholette's bioreactor under different operating conditions. The open-loop behavior is studied by means of the steady-state multiplicity areas formed by substrate feed concentration and substrate concentration in the output using the nonlinear model of the bioreactor. The stability of each steady-state inside areas is determined by a polynomial representation. The nonlinear dynamic and steady-state multiplicity areas of the Cholette's bioreactor are shown to depend on the operating conditions and concentration required. The closed-loop behavior is studied by the tuning of a set of Pareto-optimal L2/D linear controllers at a stable operating point. Numerical simulations and phase portraits are used to evaluate the control system. This paper could be a guide for theoretical and practical applications in the fields of biotechnology and automatic control.
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