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  • Title: Inhibition of synaptosomal serotonin uptake by Ketalar.
    Author: Martin DC, Adams RJ, Watkins CA.
    Journal: Res Commun Chem Pathol Pharmacol; 1988 Oct; 62(1):129-32. PubMed ID: 3205973.
    Abstract:
    The effects of the clinical preparation of ketamine, Ketalar and its preservative, benzethonium chloride on [3H]5-hydroxytryptamine uptake were studied using rat brain synaptosomes. Ketalar caused a concentration-dependent inhibition of substrate uptake by the high affinity transport site (I50 = 20.2 +/- 2.75 microM) while benzethonium chloride had no effect. Kinetic analysis indicated the inhibition to be competitive with serotonin; the apparent km (54 nM) was increased nearly two-fold at 10 microM ketamine. This action may represent a mechanism involved in ketamine anesthesia.
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