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  • Title: Cultivation of exoerythrocytic stages of Plasmodium cynomolgi, P. knowlesi, P. coatneyi, and P. inui in Macaca mulatta hepatocytes.
    Author: Millet P, Fisk TL, Collins WE, Broderson JR, Nguyen-Dinh P.
    Journal: Am J Trop Med Hyg; 1988 Dec; 39(6):529-34. PubMed ID: 3207173.
    Abstract:
    Exoerythrocytic stage parasites of Plasmodium cynomolgi, P. knowlesi, P. coatneyi, and P. inui were cultured by inoculating primary cultures of hepatocytes from Macaca mulatta with sporozoites. Less than 1% of inoculated sporozoites survived. Morphology and size of the liver stages in all 4 species were similar to in vivo descriptions and the time required for in vitro maturation correlated well with prepatent periods described.
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