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  • Title: Effect of intra-articular glucocorticoids on the disposition of sulphadimidine in chronic osteoarthritis patients.
    Author: Reeves PT, Hanrahan P, Edelman J, Ilett KF.
    Journal: Br J Clin Pharmacol; 1988 Nov; 26(5):563-8. PubMed ID: 3207561.
    Abstract:
    1. The disposition of sulphadimidine (15 mg kg-1 orally) was investigated in six chronic osteoarthritis patients (four slow and two fast acetylators) prior to and 4 days following intra-articular administration of glucocorticoids. 2. The mean (+/- s.e. mean) renal clearance of sulphadimidine was increased from 0.03 +/- 0.01 to 0.07 +/- 0.02 ml min-1 kg-1 (P = 0.01) following the administration of intra-articular steroid. 3. Mean metabolic clearance and volume of distribution data were similar on the two study days. However, two of the slow acetylators showed marked increases (63% and 193%) in metabolic clearance following steroid treatment.
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