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  • Title: Intraventricular injection of antiserum to nerve growth factor delays the development of amygdaloid kindling.
    Author: Funabashi T, Sasaki H, Kimura F.
    Journal: Brain Res; 1988 Aug 16; 458(1):132-6. PubMed ID: 3208092.
    Abstract:
    To investigate the possibility that nerve growth factor (NGF) may play some role in the development of kindling, rabbit anti-NGF serum was injected into the third ventricle on the first 3 days of daily electrical stimulation of the basolateral amygdala. The number of stimulations required to reach full amygdaloid kindling increased significantly in the rat injected with anti-NGF serum compared to that in the rat injected with normal rabbit serum. It was confirmed that anti-NGF serum did not act as an anticonvulsant. The results demonstrate that NGF may be important for the long-lasting neuronal changes induced by daily electrical stimulation of the amygdala.
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