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Title: [Clinical study of Chinese Medicine fumigation combined with "Zhuyuan Decoction" in the treatment of chronic rhinosinusitis].
Author: Li YQ, Zhang CH, Zang CP, Gu SY.
Journal: Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi; 2020 Jan; 34(1):5-9. PubMed ID: 32086888.
Abstract:
Objective:To investigate the clinical efficacy of "Zhuyuan soup" by combination with fumigation and oral administration on chronic rhinosinusitis（CRS）, further exploring effective Chinese medicine for the disease, and giving full play to the unique advantages of external treatment of traditional Chinese medicine. Method:By using randomized and positive drug controlled methods, patients with moderate-to-severe chronic rhinosinusitis were randomly divided into western medicine group and traditional Chinese medicine group, 30 cases in each group. In the western medicine group, the nasal spray hormone Budesonide was used, and the patients in the traditional Chinese medicine group were treated with the traditional Chinese medicine prescription"Zhuyuan soup"by combination with fumigation and oral administration. All of the above patients were followed up for 2 weeks, and 1 course for 1 month. Visual analogue scores were taken at each follow-up, and CT and nasal endoscopy were performed before and after treatment. Result:The total effective of "Zhuyuan soup" group was 67.1%, which was higher than that of western medicine group（59.6%）, but there was no statistically significant difference（P>0.05）. After treatment, there were no significant differences between the two groups with regard to the symptom of nasal congestion, dizziness, facial pain or fullness, dysosmia, nasal discharge or postnasal drip, total sensation, total symptom score（P>0.05）. According to the total symptom score, the effect of the two groups of patients was not significantly correlated with the gender, age, course of disease, alcohol and tobacco hobbies, previous medication and surgery（P>0.05）. Based on the results of the study, we found that the Chinese medicine group is superior to the western medicine group in improving the total feeling of the disease, dizziness or headache, facial pain or fullness, and postnasal drip, olfactory disorder. Conclusion:Both traditional Chinese medicine and western medicine are effective methods for treating chronic rhinosinusitis. Clinically, individualized comprehensive treatment should be carried out according to the patient's condition. The above methods may be applied alone or in combination with Chinese and Western medicine. Further optimization and improvement of the combination of traditional Chinese and Western medicine in chronic sinusitis can help improve the clinical efficacy and satisfaction of patients, which deserves further study. 目的：系统研究、验证“逐渊汤”熏蒸联合内服对慢性鼻窦炎的临床疗效, 进一步总结、探索治疗鼻渊的有效中药, 并发挥中医外治方法的独特优势。方法: 采用随机、阳性药物平行对照的临床研究方法, 将中-重度慢性鼻窦炎患者随机分为西药组和中药组, 每组30例。西药组患者采用鼻喷激素布地奈德, 口服克拉霉素、切诺; 中药组患者采用中药验方“逐渊汤”熏蒸联合内服方法进行治疗。上述患者均2周随访1次, 1个月为1个疗程。每次随访时进行主观症状视觉模拟量表评分, 治疗前、治疗后进行鼻窦CT及鼻内镜检查。结果: ①中药组的临床总有效率为67.1%, 高于西药组（59.6%）, 但差异无统计学意义（P>0.05）。 ②治疗后2组患者的症状评分包括鼻塞、头昏痛、面部疼痛或胀满、嗅觉障碍、鼻分泌物或鼻后滴漏、总感觉、总评分, 差异无统计学意义（P>0.05）。③以总评分计, 2组患者的疗效与患者性别、年龄、病程、是否有烟酒嗜好、既往用药和是否手术间均无显著相关（P>0.05）。④“逐渊汤”熏蒸联合内服在改善患者的疾病总感觉, 缓解头昏或头痛、面部疼痛或胀满感以及鼻后滴漏、嗅觉障碍方面的效果优于西药组。结论: 中药和西药均是治疗慢性鼻窦炎的有效方法, 临床应根据患者情况进行个体化综合治疗, 上述方法或单独应用, 或中西医结合使用。慢性鼻窦炎中西医结合诊疗方案的进一步优化完善, 有助于提高患者的临床疗效和就诊满意度, 提升诊疗体验, 值得进一步深入研究。.

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