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  • Title: Dose-dependent pharmacokinetics of metabolites of dipyrone in saliva.
    Author: Neddermann E, Rohdewald P.
    Journal: Eur J Drug Metab Pharmacokinet; 1988; 13(2):105-11. PubMed ID: 3208789.
    Abstract:
    Metabolites of dipyrone have been determined in the saliva of 18 volunteers following the oral intake of 0.5 g, 1.0 g, 1.5 g, 2.0 g and 2.5 g dipyrone. High concentrations were measured for N-methyl-aminoantipyrine (MAA), the other analgetic active metabolite, 4-aminoantipyrine was found in minor quantities only. N-formyl-antipyrine was not present in the saliva of some volunteers after low doses but could be determined following the intake of doses from 1.5 g - 2.5 g in saliva of all volunteers. N-acetyl-antipyrine appears late in saliva, acetylation rates varied greatly interindividually. Concentrations of the metabolites in saliva mimic the respective non-protein bound fraction in plasma found by other authors.
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