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  • Title: Aggressive treatment improves survival in adult acute lymphoblastic leukemia.
    Author: Smedmyr B, Killander A, Simonsson B, Sundström C.
    Journal: Eur J Haematol; 1988 Nov; 41(5):478-81. PubMed ID: 3208869.
    Abstract:
    20 consecutive adult patients with acute lymphoblastic leukemia were treated with an intense induction regimen including vincristine, doxorubicin, prednisolone, L-asparaginase and cyclophosphamide. 16 patients (80%) achieved complete remission and were then given CNS prophylaxis and 3 years of maintenance therapy. With minimum follow-up of 24 months, the median duration of first remission is 37+ months. Out of 10 patients who have completed maintenance therapy, 2 have relapsed after 14 and 22 months, respectively, and 7 are in continuous complete remission 1+-55+ months off therapy.
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