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  • Title: The acute response of indium-111 labelled platelets to arteriotomy closure.
    Author: Nash PA, Lord RS, Zhang HQ, Yeates P, Whitfeld MJ, Freund J, Pocock NA, Yeates M, Goh KH.
    Journal: J Cardiovasc Surg (Torino); 1988; 29(6):701-6. PubMed ID: 3209613.
    Abstract:
    A standard 40 mm arteriotomy was created in canine iliac and carotid arteries and then closed by either direct suture without a patch, with a vein patch or with a polytetrafluoroethylene patch (PTFE). The uptake of 111-Indium oxine labelled platelets at 2 hours after operation was compared between the groups. Arteriotomies closed with a PTFE patch demonstrated significantly greater platelet aggregation than those closed with a vein patch. Primary closure without a patch was associated with the least platelet uptake of all (PTFE versus vein patch, P less than 0.01; PTFE versus no patch, P less than 0.01; vein patch versus no patch, P less than 0.05). Light and electron microscopy confirmed the radioisotopic findings.
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