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  • Title: Mechanism of the postcoital contraceptive effect of LH-RH in the rat. I. Serum hormone levels during chronic LH-RH Administration.
    Author: Beattie CW, Corbin A, Cole G, Corry S, Jones RC, Koch K, Tracy J.
    Journal: Biol Reprod; 1977 Apr; 16(3):322-32. PubMed ID: 321040.
    Abstract:
    The mechanism of the postcoital contraceptive effect of luteinizing hormone-releasing hormone (LH-RH) was studied in the rat. 200 mcg of LH-RH administered daily over Days 1-7 of pregnancy produced a dramatic inhibition of pregnancy. This inhibition was directly correlated with induced ''surges'' in serum LH over Days 1-4. Serum follicle stimulating hormone and prolactin were, in general, reduced over this same time period. A 48-hour delay in the preimplantation (Day 3) ''surge'' in serum estradiol accompanied by a significant (ps less than .05 and less than .01) reduction in serum progesterone on Days 3, 4, 6, and 7 was also observed. The delayed ''surge'' in serum estradiol on Day 5 and reduction in serum progesterone was correlated with an increase in folliculogenesis and luteolysis of established corpora lutea, respectively. These data suggest that in the rat LH-RH induces a rise in serum LH which is luteolytic during pregnancy and delays the serum estradiol surge necessary for normal implantation.
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