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  • Title: Tetrodotoxin sensitivity of high K+-induced 86Rb efflux in the duodenal circular muscle of pigs.
    Author: Kondoh T, Kimura I, Kimura M.
    Journal: Jpn J Pharmacol; 1988 Oct; 48(2):294-8. PubMed ID: 3210454.
    Abstract:
    The 86Rb efflux by high K+ was measured simultaneously during the mechanical responses in pig duodenal circular muscle using a superfusion technique. A slightly higher K+ (17.7-23.6 mM) simultaneously induced tetrodotoxin (TTX)-sensitive relaxation and 86Rb efflux. Much higher K+ (47.2-143.4 mM) contracted and also increased the 86Rb efflux markedly, but the extent of TTX-sensitive efflux remained the same as the one at 17.7-23.6 mM K+, indicating that the TTX-insensitive efflux was contraction-related. The former efflux may lead to hyperpolarization linked to relaxation.
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