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  • Title: Visible-Light-Mediated β-C-H gem-Difluoroallylation of Aldehydes and Cyclic Ketones through C-F Bond Cleavage of 1-Trifluoromethyl Alkenes.
    Author: Anand D, Sun Z, Zhou L.
    Journal: Org Lett; 2020 Mar 20; 22(6):2371-2375. PubMed ID: 32134274.
    Abstract:
    gem-Difluoroalkene bearing a carbonyl group is a challenging target to synthesize by conventional methods. Herein we report a mild and concise route to access the target compounds through the visible-light-mediated direct β-C-H gem-difluoroallylation of aliphatic aldehydes and cyclic ketones. Upon a synergistic combination of photoredox catalysis and organocatalysis, various α-CF3 alkenes were employed as the gem-difluoroallylation reagents via the C-F bond cleavage.
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