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  • Title: Cell-mediated immunity in experimental Nocardia asteroides infection.
    Author: Sundararaj T, Agarwal SC.
    Journal: Infect Immun; 1977 Feb; 15(2):370-5. PubMed ID: 321348.
    Abstract:
    Experimental mycetoma-like lesions developed in guinea pigs after subcutaneous injection of Nocardia asteroides. Although delayed hypersensitivity appeared earlier, increased macrophage migration inhibition and microbicidal activity appeared after 7 weeks. When the lesions healed, high cell-mediated immunity was present. Cell-mediated immunity was transferred to normal recipient guinea pigs from healed donor guinea pigs by spleen cell transfer. Recipient guinea pigs showed marked protection against challenge with N. asteroides.
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