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  • Title: Blocking HbS Polymerization in SCD.
    Author: Lettre G.
    Journal: Cell; 2020 Mar 05; 180(5):819. PubMed ID: 32142671.
    Abstract:
    Sickle cell disease (SCD) is caused by a point mutation in the β-globin gene that creates hemoglobin S (HbS). Upon deoxygenation, HbS forms long polymers that distort the shape of red blood cells, causing hemolysis and vaso-occlusion. Voxelotor inhibits HbS polymerization, the root cause of SCD complications. To view this Bench to Bedside, open or download the PDF.
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