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  • Title: Synergy between a non-neuroleptic thioxanthene stereo-isomer and penicillin in vivo.
    Author: Kristiansen JE, Sebbesen O, Frimodt-Møller N, Aaes-Jørgensen T, Hvidberg EF.
    Journal: APMIS; 1988 Dec; 96(12):1079-84. PubMed ID: 3214583.
    Abstract:
    Some neuroleptic drugs of the phenothiazine and thioxanthene groups have an antimicrobial effect in vitro. This is also true for neuroleptically inactive stereo-isomeric analogs of the thioxanthenes e.g. trans(E)-clopenthixol (t-CPT). In a murine pneumococcus peritonitis model t-CPT demonstrated a slight, but non-significant antibacterial effect in doses of 0.3-0.9 mg per mouse, while higher doses seemed to enhance the bacterial virulence. If combined with subtherapeutic doses of penicillin, a significantly higher survival rate was obtained compared with either drug given alone. In vitro studies demonstrated a similar synergistic effect. These results indicate that at least one non-neuroleptic thioxanthene stereo-isomer has an antibiotic potential also in vivo. The mechanism of action is not known.
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