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  • Title: A fast detection of peroxynitrite in living cells.
    Author: Li M, Gong X, Li HW, Han H, Shuang S, Song S, Dong C.
    Journal: Anal Chim Acta; 2020 Apr 15; 1106():96-102. PubMed ID: 32145860.
    Abstract:
    Peroxynitrite (ONOO-) plays a crucial role in the regulation of diverse pathophysiological processes, and high level of ONOO- is profound association with numerous diseases. Herein, we developed an anthraquinone-based fluorescent probe L for ONOO- determination by a new recognition mechanism: amido oxidized nitroso-group by ONOO-. Probe L with amine-based recognition receptor is more selective to ONOO- than other reactive oxygen species, including H2O2 and ClO-. Furthermore, ONOO- could be rapidly detected by probe L with a Limit of Detection of 13 nM. More importantly, L could be used to monitor intracellular ONOO- in SMMC-7721 cells.
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