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  • Title: Cholinergic muscarinic receptors in rat cochlea.
    Author: van Megen YJ, Klaassen AB, Rodrigues de Miranda JF, Kuijpers W.
    Journal: Brain Res; 1988 Nov 22; 474(1):185-8. PubMed ID: 3214711.
    Abstract:
    Specific 3H-1-quinuclidinylbenzilate (3H-1-QNB) binding to rat cochlea homogenates occurs to a homogeneous class of binding sites with Kd = 0.13 +/- 0.01 nM and Bmax = 0.57 +/- 0.07 fmol per cochlea. Binding is stereoselectively inhibited by benzetimide enantiomers. Dexetimide was more effective than levetimide in displacing 3H-1-QNB from its binding sites (Ki = 4 x 10(-10) M and 6.5 x 10(-6) M, respectively). Pirenzepine inhibits 3H-1-QNB binding with low affinity (Ki = 2 x 10(-6) M), classifying the binding sites as muscarinic M2 receptors.
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