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  • Title: Design of AIEgens for near-infrared IIb imaging through structural modulation at molecular and morphological levels.
    Author: Li Y, Cai Z, Liu S, Zhang H, Wong STH, Lam JWY, Kwok RTK, Qian J, Tang BZ.
    Journal: Nat Commun; 2020 Mar 09; 11(1):1255. PubMed ID: 32152288.
    Abstract:
    Fluorescence imaging in near-infrared IIb (NIR-IIb, 1500-1700 nm) spectrum holds a great promise for tissue imaging. While few inorganic NIR-IIb fluorescent probes have been reported, their organic counterparts are still rarely developed, possibly due to the shortage of efficient materials with long emission wavelength. Herein, we propose a molecular design philosophy to explore pure organic NIR-IIb fluorophores by manipulation of the effects of twisted intramolecular charge transfer and aggregation-induced emission at the molecular and morphological levels. An organic fluorescent dye emitting up to 1600 nm with a quantum yield of 11.5% in the NIR-II region is developed. NIR-IIb fluorescence imaging of blood vessels and deeply-located intestinal tract of live mice based on organic dyes is achieved with high clarity and enhanced signal-to-background ratio. We hope this study will inspire further development on the evolution of pure organic NIR-IIb dyes for bio-imaging.
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