These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Alteration of inositol phospholipid metabolism in rat cortex by lithium but not carbamazepine.
    Author: Elphick M, Taghavi Z, Powell T, Godfrey PP.
    Journal: Eur J Pharmacol; 1988 Nov 08; 156(3):411-4. PubMed ID: 3215284.
    Abstract:
    The effect of carbamazepine on inositol phospholipid metabolism was investigated in rat cerebral cortex. The stimulation of inositol phosphate formation by 5-HT (10 microM), carbachol (100 microM) and noradrenaline (30 microM) was not significantly altered by carbamazepine in vitro. 14 days treatment of rats in vivo with carbamazepine was similarly without effect on these parameters. In contrast 14 days treatment with LiCl reduced the agonist responses by 25-50%. The results are discussed in relation to the therapeutic actions of these drugs.
    [Abstract] [Full Text] [Related] [New Search]