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  • Title: The effect of a new gastric proton pump inhibitor on serotonin-induced gastric mucosal lesions in rats.
    Author: Tsukamoto Y, Nakazawa S, Segawa K, Goto H, Fukui A, Takano K, Hase S, Arisawa T, Osada T, Kawabe Y.
    Journal: Gastroenterol Jpn; 1988 Oct; 23(5):501-5. PubMed ID: 3215434.
    Abstract:
    The anti-ulcer effect of NC-1300, a new proton pump inhibitor, and its effect on gastric mucosal blood flow were studied in rats. Acute gastric mucosal lesions were induced by the subcutaneous administration of serotonin, 20 mg/kg. Using the electrolytically generated hydrogen gas clearance technique, it was determined that such gastric ulceration resulted mainly from a decrease in gastric mucosal blood flow. These lesions could be inhibited to a statistically significant extent by the intravenous administration of NC-1300, 20 mg/kg, which markedly inhibited gastric acid secretion. However, the serotonin-induced decrease in gastric mucosal blood flow could not be prevented by pretreatment with 20 mg/kg of NC-1300. It was concluded that protection against serotonin-induced gastric ulceration can be achieved by markedly inhibiting gastric acid secretion.
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