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  • Title: [Several aspects of the pathogenesis of disturbances of hemostasis in patients with diffuse toxic goiter].
    Author: Oleĭnik VA, Matiashina GI.
    Journal: Ter Arkh; 1988; 60(9):43-6. PubMed ID: 3217879.
    Abstract:
    Components of the kallikrein-kinin system of the blood and some hemostatic indices were studied in parallel in 32 patients with diffuse toxic goiter. A decrease in the levels of prekallikrein, kininogen, the activity of kallikrein and kininase inhibitors in the blood plasma of the examinees resulted in raised activity of the kallikrein-kinin system in decompensated thyrotoxicosis. Hemostatic changes were characterized by signs of chronic disseminated intravascular coagulation. It was shown that kinin formation and blood coagulation were correlated. A certain parallelism in the increment of the activity of the kinin system and disorders of hemocoagulation was noted with an increase in a degree of severity of thyrotoxicosis. A tendency to improved indices was also noted after thyrostatic therapy.
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