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  • Title: [Polyamines as a prognostic criterion of the duration of clinico-hematologic remission in acute leukemia in children].
    Author: Kovtunova ME, Voronchikhina LD, Riabova TI, Riabov NV.
    Journal: Ter Arkh; 1988; 60(9):77-9. PubMed ID: 3217885.
    Abstract:
    The authors reported the results of retrospective analysis of the level of polyamines in urine and the duration of clinicohematological remission in 25 AL children aged 3 to 14. Of this number 23 patients suffered from acute lymphoblastic leukemia, 2--from acute myeloblastic leukemia. Direct correlation between polyamine changes during a course of chemotherapy and the duration of remission was established. Longer duration was observed in the patients in whom a 2-fold rise of the level of all polyamines, especially spermidine, followed the administration of a cytostatic within the first 24-72 h. On the discontinuation of therapy a certain decrease in polyamine excretion with urine was observed in these children as compared to the level determined on their admission to hospital.
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