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Title: A dual photoredox-nickel strategy for remote functionalization via iminyl radicals: radical ring-opening-arylation, -vinylation and -alkylation cascades. Author: Dauncey EM, Dighe SU, Douglas JJ, Leonori D. Journal: Chem Sci; 2019 Sep 07; 10(33):7728-7733. PubMed ID: 32180920. Abstract: A divergent strategy for the remote arylation, vinylation and alkylation of nitriles is described. These processes proceed through the photoredox generation of a cyclic iminyl radical and its following ring-opening reaction. The distal nitrile radical is then engaged in nickel-based catalytic cycles to form C-C bonds with aryl bromides, alkynes and alkyl bromides.[Abstract] [Full Text] [Related] [New Search]