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  • Title: Physico-chemical properties and stabilities of the highly potent calcium antagonist benidipine hydrochloride.
    Author: Suzuki H, Ono E, Ueno H, Takemoto Y, Nakamizo N.
    Journal: Arzneimittelforschung; 1988 Nov; 38(11A):1671-6. PubMed ID: 3219139.
    Abstract:
    (+/-)-(R*)-2,6-Dimethyl-4-(m-nitrophenyl)-1,4-dihydropyridine-3, 5-dicarboxylic acid (R*)-1-benzyl-3-piperidinyl ester, methyl ester hydrochloride (benidipine hydrochloride, KW-3049), a highly potent calcium antagonist, was examined to clarify its physico-chemical properties, i.e. melting point, spectra (UV, IR, NMR, MS), X-ray diffraction pattern, thermal analysis, solubilities, pKá, partition coefficient and chromatography (TLC, HPLC). The stabilities of KW-3049 were studied under various conditions by HPLC. KW-3049 in solid state was very stable to heat and moisture, and fairly stable to light.
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