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  • Title: Levo-carnitine, its derivatives, and free fatty acids in serum, heart, liver, and muscle of both tumoral and alcoholic rats.
    Author: De la Morena E, Berlanas EJ, Gomez C.
    Journal: Clin Ther; 1988; 10(6):672-7. PubMed ID: 3219683.
    Abstract:
    We present a comparative study of carnitine-related fatty acid metabolism in rats bearing a Yoshida sarcoma, in chronic alcoholic rats, and in control rats. Levels of levo-carnitine, acetylcarnitine, acylcarnitine, and free fatty acids were studied in serum and in different tissues--liver, heart, and skeletal muscle--of each group of rats. Chronic alcoholic rats showed high levels of free fatty acids and elevated levo-carnitine and acetylcarnitine levels relative to those of the controls. Biosynthesis of carnitine appeared to be increased, whereas fatty acid oxidation was depressed. Tumor-bearing rats also showed high levels of free fatty acids in both serum and tissues. However, levels of levo-carnitine were decreased in this group. It seems that the tumor not only utilizes the precursors of carnitine biosynthesis but also increases carnitine expenditure.
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