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  • Title: Comparison of paraquat-specific murine monoclonal antibodies produced by in vitro and in vivo immunization.
    Author: Johnston SC, Bowles M, Winzor DJ, Pond SM.
    Journal: Fundam Appl Toxicol; 1988 Aug; 11(2):261-7. PubMed ID: 3220205.
    Abstract:
    The techniques of in vitro and in vivo immunization have been used to produce murine hybridomas secreting anti-paraquat IgM and IgG antibodies, respectively. The monoclonal antibodies from these IgM-secreting and IgG-secreting cell lines have been purified by HPLC and characterized by ELISA for their affinities to eliciting antigen and cross-reactivity. Both antibody preparations exhibited high selectivity and similar affinities for paraquat. There was only a minor degree of interaction with a range of paraquat analogs that differed in the nature and position of group substituents.
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